Postnatal Erythropoietin Mitigates Impaired Cerebral Cortical Development Following Subplate Loss from Prenatal Hypoxia–Ischemia
نویسندگان
چکیده
منابع مشابه
Postnatal Erythropoietin Mitigates Impaired Cerebral Cortical Development Following Subplate Loss from Prenatal Hypoxia-Ischemia.
Preterm birth impacts brain development and leads to chronic deficits including cognitive delay, behavioral problems, and epilepsy. Premature loss of the subplate, a transient subcortical layer that guides development of the cerebral cortex and axonal refinement, has been implicated in these neurological disorders. Subplate neurons influence postnatal upregulation of the potassium chloride co-t...
متن کاملSubplate and the Formation of the Earliest Cerebral Cortical Circuits
The billions of cells and trillions of connections of the human brain are generated from the complex interactions between a developmental genetic programme and the environment. The resulting embryo is the ultimate readout of our genome; a combination of genetic susceptibility and environmental perturbations can lead to several devastating neurological and psychiatric conditions. The cerebral co...
متن کاملSubplate Neurons: Crucial Regulators of Cortical Development and Plasticity
The developing cerebral cortex contains a distinct class of cells, subplate neurons, which form one of the first functional cortical circuits. Subplate neurons reside in the cortical white matter, receive thalamic inputs and project into the developing cortical plate, mostly to layer 4. Subplate neurons are present at key time points during development. Removal of subplate neurons profoundly af...
متن کاملSecretory function in subplate neurons during cortical development
Subplate cells are among the first generated neurons in the mammalian cerebral cortex and have been implicated in the establishment of cortical wiring. In rodents some subplate neurons persist into adulthood. Here we would like to highlight several converging findings which suggest a novel secretory function of subplate neurons during cortical development. Throughout the postnatal period in rod...
متن کاملPrenatal Origin and Early Postnatal Development
DOI 10.1027/0044-3409.216.3.148 Abstract. The spontaneous movements of the newborn infant have a long prenatal history. From 8 weeks postmenstrual age onward the fetus moves in distinct motor patterns. There is no period of amorphic and random movements. The patterns are easily recognizable, as all of them can be seen after birth. The human neonate demonstrates a continuum of motor patterns fro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cerebral Cortex
سال: 2014
ISSN: 1047-3211,1460-2199
DOI: 10.1093/cercor/bhu066